Via MetaFilter: The Electro-Plasmic Hydrocephalic Genre-Fiction Generator, an excruciatingly accurate flowsheet for steampunk / cyberpunk / fantasy fiction. This is from Wondermark, David Malki's "illustrated jocularity" based on Victorian clipart. See examples - In which Sparky changes Ownership, In which a Heroine scowls a lot, and In which a Cat plays the Piano, In which it Keeps Going ("You'll not hear much of anything once my Cynthia finishes initiating her binary defense protocols") - and the Archive.
I've already enthused about 2D Googles (illustrator Sydney Padua's development blog for a proto-strip about Babbage and Lovelace as a crimefighting duo).
XKCD, "A webcomic of sarcasm, romance, math and language", by Randall Munroe: generally recommended on the science/computing circuit, as well as Language Log. See examples - Theft of the Magi, Iambic pentameter, and Beliefs - and the Archive. Oh, and the XKCD guest slot at Wondermark.
The Abominable Charles Christopher by Karl Kerschl - "the adventures of a dim-witted yeti through a forest full of colourful animal characters". Hard to tell what this is about: Charles pursues a rather dark and mystical quest amid light relief from anthropomorphized forest creatures, but I'm not sure whether to take it at face value or if the creatures are actually human and have been somehow transformed. See examples - Blunt force drama, Private practice, Time is relative, and The Godfather - and the Archive.
Digger, by Ursula Vernon. "A wombat. A dead god. A very peculiar epic", starting here.